Selective injections of vasoactive drugs have been used during renal angiography in 86 kidneys of patients with hypertension and/or renal parenchymal diseases. The effects have been evaluated from the vessels diameter variations and the intensity of nephrographic opacification. Dopamine (DOP) (50 μg), bradikinin (BK) and prostaglandins E2 (PGE2) resulted vasodilating; hydrocortisone (CORT), acetyl salicylic acid (ASA), prostaglandins (PGF2α) and dopamine overdose (DOP o.d.) (200-400 μg) proved vasoconstricting. In the two renal vascular compartments, medullax with juxta-medullary cortex and outer cortex (that correspond to interlobar with arcuate arteries and interlobular arteries, respectively) the effects were different. The vasodilators DOP and BK showed a preferential action: the former at cortical, the latter at interlobar level; they even resolved spontaneous spasms or spasms vasoconstrictor-induced, operating better in their own preferential vascular areas. The vasoconstrictors CORT, ASA and PGF2α operated preferentially at the cortical level. The method also allows to demonstrate the type of receptors (Dopa) exploited by DOP in its vasodilating activity. The clinical use of these results is recommended to prevent or avoid functional changes which develop in diagnostic and therapeutic angiographic procedures.
ANGIOGRAPHIC EVALUATIONS ON THE INFLUENCE OF VASOACTIVE DRUGS IN RENAL VASCULAR COMPARTMENTS.
FELTRIN, GIAMPIETRO;MIOTTO, DIEGO;CHIESURA CORONA, MATTEO;MUZZIO, PIER CARLO;
1985
Abstract
Selective injections of vasoactive drugs have been used during renal angiography in 86 kidneys of patients with hypertension and/or renal parenchymal diseases. The effects have been evaluated from the vessels diameter variations and the intensity of nephrographic opacification. Dopamine (DOP) (50 μg), bradikinin (BK) and prostaglandins E2 (PGE2) resulted vasodilating; hydrocortisone (CORT), acetyl salicylic acid (ASA), prostaglandins (PGF2α) and dopamine overdose (DOP o.d.) (200-400 μg) proved vasoconstricting. In the two renal vascular compartments, medullax with juxta-medullary cortex and outer cortex (that correspond to interlobar with arcuate arteries and interlobular arteries, respectively) the effects were different. The vasodilators DOP and BK showed a preferential action: the former at cortical, the latter at interlobar level; they even resolved spontaneous spasms or spasms vasoconstrictor-induced, operating better in their own preferential vascular areas. The vasoconstrictors CORT, ASA and PGF2α operated preferentially at the cortical level. The method also allows to demonstrate the type of receptors (Dopa) exploited by DOP in its vasodilating activity. The clinical use of these results is recommended to prevent or avoid functional changes which develop in diagnostic and therapeutic angiographic procedures.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
