Padua Research Archive, l’archivio istituzionale della produzione scientifica dell’Università degli Studi di Padova, ha lo scopo di raccogliere, documentare, conservare e pubblicare, anche ad accesso aperto, i prodotti della ricerca dell’Ateneo. Padua Research Archive utilizza la piattaforma IRIS (Institutional Research Information System) sviluppata da Cineca.
EnglishThe synthesis and photobiological activity of new benzo- and tetrahydrobenzo-furocoumarins are described. In order to evaluate the biological activity of these compounds, inhibition of growth assay was performed on human neoplastic cell lines (HL-60 and HeLa), in the dark and after UV irradiation. Some of the new structures revealed strong photobiological activity, so that their affinity for the macromolecule in vitro was studied. DNA binding was evaluated using various techniques, such as flow linear dichroism, fluorimetric titration and thermal transition experiments. The capacity of the various benzo- and tetrahydrobenzo-furocoumarins to photoreact with DNA was studied following photoadduct formation by means of spectrophotometric measurements
| Titolo: | Benzo- and tetrahydrobenzo-furocoumarins: new potential photochemotherapeutic drugs. |
| Autori: | |
| Data di pubblicazione: | 1997 |
| Rivista: | |
| Abstract: | The synthesis and photobiological activity of new benzo- and tetrahydrobenzo-furocoumarins are described. In order to evaluate the biological activity of these compounds, inhibition of growth assay was performed on human neoplastic cell lines (HL-60 and HeLa), in the dark and after UV irradiation. Some of the new structures revealed strong photobiological activity, so that their affinity for the macromolecule in vitro was studied. DNA binding was evaluated using various techniques, such as flow linear dichroism, fluorimetric titration and thermal transition experiments. The capacity of the various benzo- and tetrahydrobenzo-furocoumarins to photoreact with DNA was studied following photoadduct formation by means of spectrophotometric measurements |
| Handle: | http://hdl.handle.net/11577/138222 |
| Appare nelle tipologie: | 01.01 - Articolo in rivista |
File in questo prodotto:
Copyright © 2020