The balance of CD4+ and CD8+ T cells in humans is controlled by a major autosomal gene. Here, Alberto Amadori and colleagues propose that in view of the high CD4+ cell turnover during HIV infection, individuals genetically predisposed to a high CD4:CD8 ratio can withstand HIV-associated CD4+ cell losses better than those predisposed to a low ratio.
CD4:CD8 ratio and HIV infection: The 'tap-and-drain' hypothesis
AMADORI, ALBERTO;
1996
Abstract
The balance of CD4+ and CD8+ T cells in humans is controlled by a major autosomal gene. Here, Alberto Amadori and colleagues propose that in view of the high CD4+ cell turnover during HIV infection, individuals genetically predisposed to a high CD4:CD8 ratio can withstand HIV-associated CD4+ cell losses better than those predisposed to a low ratio.File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
