PEGylation defines the modification of a protein, peptide or non-peptide molecule by the linking of one or more poly(ethylene glycol) (PEG) chains. This polymer appeared the best choice being non-toxic, non-immunogenic, non-antigenic, highly soluble in water and FDA approved. The PEG-drug conjugates take advantages from: i) a prolonged residence in body, ii) a decreased degradation by metabolic enzymes, iii) a reduction or elimination of protein immunogenicity. Thanks to these favorable properties, PEGylation is now playing an important role in drug delivery enhancing thepotentials of peptides and proteins as therapeutic agents.
PEGylation, successful approach to drug delivery.
PASUT, GIANFRANCO
2005
Abstract
PEGylation defines the modification of a protein, peptide or non-peptide molecule by the linking of one or more poly(ethylene glycol) (PEG) chains. This polymer appeared the best choice being non-toxic, non-immunogenic, non-antigenic, highly soluble in water and FDA approved. The PEG-drug conjugates take advantages from: i) a prolonged residence in body, ii) a decreased degradation by metabolic enzymes, iii) a reduction or elimination of protein immunogenicity. Thanks to these favorable properties, PEGylation is now playing an important role in drug delivery enhancing thepotentials of peptides and proteins as therapeutic agents.File in questo prodotto:
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