We show that FbsA, a cell wall protein of the bacterium Streptococcus agalactiae, promotes large-scale aggregation of human plasma fibrinogen, leading to the formation of a semiflexible polymerlike network. This extensive aggregation process takes place not only in solution, but also on FbsA-functionalized colloidal particles, and leads to the formation of a thick layer on the bacterial cell wall itself, which becomes an efficient mask against phagocytosis.
Titolo: | FbsA-driven fibrinogen polymerization: A bacterial "Deceiving strategy" | |
Autori: | ||
Data di pubblicazione: | 2006 | |
Rivista: | ||
Abstract: | We show that FbsA, a cell wall protein of the bacterium Streptococcus agalactiae, promotes large-scale aggregation of human plasma fibrinogen, leading to the formation of a semiflexible polymerlike network. This extensive aggregation process takes place not only in solution, but also on FbsA-functionalized colloidal particles, and leads to the formation of a thick layer on the bacterial cell wall itself, which becomes an efficient mask against phagocytosis. | |
Handle: | http://hdl.handle.net/11577/153367 | |
Appare nelle tipologie: | 01.01 - Articolo in rivista |
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