Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by progressive loss of motor neurons. Approximately 10% of ALS cases are familial, with the remaining being sporadic. Although the aetiology of sporadic ALS (SALS) is largely unknown, familial and epidemiological data indicate that genetic factors may contribute to its pathogenesis.
DPP6 gene variability confers increased risk of developing sporadic ALS in Italian patients.
BRIANI, CHIARA;
2008
Abstract
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by progressive loss of motor neurons. Approximately 10% of ALS cases are familial, with the remaining being sporadic. Although the aetiology of sporadic ALS (SALS) is largely unknown, familial and epidemiological data indicate that genetic factors may contribute to its pathogenesis.
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