A relatively large BACE1 inhibitor containing a hydroxyethylamine aspartyl protease inhibitor motif was identified by high-throughput screening, and has inspired the design of new “lighter”, biologically active derivatives, representing a promising new class anti-Alzheimer's drugs.
alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors
BORTOLATO, ANDREA;MORO, STEFANO;
2008
Abstract
A relatively large BACE1 inhibitor containing a hydroxyethylamine aspartyl protease inhibitor motif was identified by high-throughput screening, and has inspired the design of new “lighter”, biologically active derivatives, representing a promising new class anti-Alzheimer's drugs.
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