Phenylalanine and tyrosine kinetics in compensated liver cirrhosis: effects of meal ingestion.

We explored the mechanism (s) of increased aromatic amino acids concentrations in liver cirrhosis using phenylalanine and tyrosine isotope infusions in male patients with compensated cirrhosis (five in Child Class A, three in B) and in eight matched healthy controls, in both postabsorptive and fed states.In summary, in compensated liver cirrhosis under fasted and fed states shoved that hypertyrosinemia observed in cirrhotic patients is due to increased total tirosine apppearance and to hydroxylation of tyrosine. The hypephenilalaninemia include increased production and decreased disposal.