A series of PTH hybrids containing a diamine [NH2(CH2) n NH2; n = 4, 5, 6] in the C-terminal position was synthesized based on the H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH2 (Har = homoarginine) template. The compounds were pharmacologically characterized at PTH1R receptors for agonist activity
Role of the Guanidine Group in Position 11 of PTH(1-11) Analogues.
CAPORALE, ANDREA;SCHIEVANO, ELISABETTA;MAMMI, STEFANO;PEGGION, EVARISTO
2009
Abstract
A series of PTH hybrids containing a diamine [NH2(CH2) n NH2; n = 4, 5, 6] in the C-terminal position was synthesized based on the H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH2 (Har = homoarginine) template. The compounds were pharmacologically characterized at PTH1R receptors for agonist activityFile in questo prodotto:
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