Effect of prothrombin 19911 A>G polymorphism on the risk of cerebralsinus-venous thrombosis.

Eur J Neurol. 2010 Dec;17(12):1482-5. Effect of prothrombin 19911 A>G polymorphism on the risk of cerebral sinus-venous thrombosis. Martinelli I, Bucciarelli P, De Stefano V, Passamonti SM, Menegatti M, Tormene D, Tosetto A, Mannucci PM. A. Bianchi Bonomi Haemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University of Milan, Milan, Italy. martin@policlinico.mi.it BACKGROUND AND PURPOSE: The A>G polymorphism at position 19911 of the prothrombin gene is associated with a mildly increased risk of venous thromboembolism, alone or in association with such common thrombophilia mutations as factor V Leiden and prothrombin 20210 GA. Its role in cerebral sinus-venous thrombosis (CSVT) is not known. METHODS: The presence of prothrombin 19911 A>G was investigated in a case–control study of 107 patients with cerebral thrombosis and factor V Leiden (n = 25), prothrombin 20210 GA (n = 47), without known thrombophilia (n = 35) and 842 healthy individuals with the corresponding coagulation profile. RESULTS: Prothrombin 19911 A>G did not increase the risk of CSVT in carriers of factor V Leiden (adjusted odds ratio 1.6, 95%CI 0.6–4.7), prothrombin 20210 GA (odds ratio 1.1, 95%CI 0.6–2.2), nor in patients without known thrombophilia (odds ratio 1.3, 95%CI 0.5–3.1). CONCLUSIONS: Prothrombin 19911 A>G polymorphism does not appear to be a risk factor for CSVT, alone or in association with factor V Leiden or prothrombin 20210GA. © 2010 The Author(s). European Journal of Neurology © 2010 EFNS. PMID: 20482605 [PubMed - indexed for MEDLINE]