Fully symmetrical functionalization of multivalent scaffold molecules on solid support

A new methodology for the functionalization of scaffold molecules on solid support is described, which does not require (partial) protection of the scaffold or a special functional group arrangement on it, while maintaining scaffold symmetry in the final product. As an illustration of the versatility of this approach, three scaffold molecules (1,3,5-tris(aminomethyl)-2,4,6-triethylbenzene, tris(2-aminoethyl)amine, and triazacyclononane) were functionalized with different functional groups in a moderate to high yield and purity. The developed protocol is a valuable tool for an easy access to multivalent molecules. (c) 2006 Elsevier Ltd. All rights reserved