Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and other diseases. Using a virtual screening approach, we have identified the ellagic acid, a naturally occurring tannic acid derivative, as a novel potent CK2 inhibitor. At present, ellagic acid represents the most potent known CK2 inhibitor (K(i) = 20 nM).

Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.

COZZA, GIORGIO;BONVINI, PAOLO;ZORZI, ELISA;POLETTO, GIORGIA;PAGANO, MARIO ANGELO PRIMO;SARNO, STEFANIA;DONELLA, ARIANNA;ZAGOTTO, GIUSEPPE;ROSOLEN, ANGELO;PINNA, LORENZO;MEGGIO, FLAVIO;MORO, STEFANO
2006

Abstract

Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and other diseases. Using a virtual screening approach, we have identified the ellagic acid, a naturally occurring tannic acid derivative, as a novel potent CK2 inhibitor. At present, ellagic acid represents the most potent known CK2 inhibitor (K(i) = 20 nM).
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/2439390
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