The topical anti-inflammatory activity of Solenostemma argel Hayne leaves was evaluated using the Croton oil ear test in mice. A bioassayguided fractionation procedure led to a highly active chloroform extract: at 300 g/cm2, it induced 73% oedema reduction, while the reference drug indomethacin (100g/cm2) induced 56% reduction. The extract contained a new pregnene glycoside (1, solenoside A) and the known 14,15-dihydroxy-4pregnene-3,20 dione (2), kaempferol-3-O-glucoside (3) and kaempferol-3-O-rutinoside (4). Their structures were determined by ID and 2D NMR experiments as well as HRMS. Compounds 2 and 4 showed anti-inflammatory activity comparable to that of indomethacin.

Topical anti-inflammatory activity of Solenostemma argel leaves

INNOCENTI, GABBRIELLA;DALL'ACQUA, STEFANO;
2005

Abstract

The topical anti-inflammatory activity of Solenostemma argel Hayne leaves was evaluated using the Croton oil ear test in mice. A bioassayguided fractionation procedure led to a highly active chloroform extract: at 300 g/cm2, it induced 73% oedema reduction, while the reference drug indomethacin (100g/cm2) induced 56% reduction. The extract contained a new pregnene glycoside (1, solenoside A) and the known 14,15-dihydroxy-4pregnene-3,20 dione (2), kaempferol-3-O-glucoside (3) and kaempferol-3-O-rutinoside (4). Their structures were determined by ID and 2D NMR experiments as well as HRMS. Compounds 2 and 4 showed anti-inflammatory activity comparable to that of indomethacin.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/2443189
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