We present a pulse sequence based on solute-to-solvent NOE enhancement and aimed at the detection of intermolecular NOE's. Thus, a W3 pulse cluster is used to selectively filter the solvent signals in a DPFGSE sequence. The sequence has been tested on a sample of glucose dissolved in two binary aqueous mixtures (water-acetonitrile and water-DMSO). We show how the resulting enhancements may derive from intermolecular cross-relaxation or, in the water-DMSO sample, also from chemical exchange. In each case, a quantitative interpretation of the data is also supplied, both in terms of local enrichment in one specific solvent (preferential solvation), and by means of a kinetic model for a two-site chemical exchange.

Detecting Intermolecular NOEs by Means of a Novel DPFGSE Pulse Sequence. Application to the Solvation of Carboydrates in Binary Mixtures

BAGNO, ALESSANDRO;RASTRELLI, FEDERICO;SCORRANO, GIANFRANCO
2004

Abstract

We present a pulse sequence based on solute-to-solvent NOE enhancement and aimed at the detection of intermolecular NOE's. Thus, a W3 pulse cluster is used to selectively filter the solvent signals in a DPFGSE sequence. The sequence has been tested on a sample of glucose dissolved in two binary aqueous mixtures (water-acetonitrile and water-DMSO). We show how the resulting enhancements may derive from intermolecular cross-relaxation or, in the water-DMSO sample, also from chemical exchange. In each case, a quantitative interpretation of the data is also supplied, both in terms of local enrichment in one specific solvent (preferential solvation), and by means of a kinetic model for a two-site chemical exchange.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/2444116
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