The development of synthetic agents able to hydrolytically cleave DNA with high efficiency and selectivity is a fascinating challenge that will show the way to obtaining artificial nucleases able to compete with the natural enzymes. This Feature Article highlights the progress reported toward the realization of synthetic nucleases with particular attention to the strategies that can be pursued to improve efficiency and sequence selectivity.

Artificial MetalloNucleases

MANCIN, FABRIZIO;SCRIMIN, PAOLO MARIA;TONELLATO, UMBERTO
2005

Abstract

The development of synthetic agents able to hydrolytically cleave DNA with high efficiency and selectivity is a fascinating challenge that will show the way to obtaining artificial nucleases able to compete with the natural enzymes. This Feature Article highlights the progress reported toward the realization of synthetic nucleases with particular attention to the strategies that can be pursued to improve efficiency and sequence selectivity.
2005
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/2445768
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