PURPOSE: To study child-parent similarities and the heritability of corneal shape by applying a variance component model to videokeratographic data. METHODS: Sixteen astigmatic (keratometric cylinder >/= 1.0 D) and 18 nonastigmatic (keratometric cylinder < 1.0 D) children, 7-14 years of age (mean age, 9.5 years), were enrolled with their parents. Corneal curvature, corneal astigmatism (axis and magnitude), asphericity, corneal uniformity index, and Rabinowitz McDonnell inferior-superior dioptric asymmetry value (I-S value), as well as spherical and astigmatic topographic patterns, were determined by a corneal topographer. Child-parent comparisons were assessed through a 1-way analysis of variance and the chi test. For corneal curvature, corneal astigmatism, and asphericity, heritability was estimated by a variance component model after adjustments were made for age and sex. RESULTS: Both astigmatic and nonastigmatic children showed steeper keratometric values than their parents (P < 0.05). The axis values of corneal astigmatism showed no statistically significant difference (P = 0.684) between astigmatic offspring and their parents, whereas the magnitude values were significantly higher (P < 0.001) in astigmatic children. Altogether, 68% (95% confidence interval [CI], 66%-72%) of child-parent comparisons showed the same topographic pattern between parents and their offspring. Heritability values (48%; 95% CI, 36%-57%) were statistically significant for corneal curvature (P < 0.00001) and <30% for corneal astigmatism and asphericity. CONCLUSIONS: The application of a variance component model to videokeratographic child-parent comparisons suggests that the genetic contribution to corneal shape affects corneal curvature rather than corneal astigmatism.

Heritability of corneal curvature and astigmatism - A videokeratographic child-parent comparison study

GREGORI, DARIO;
2007

Abstract

PURPOSE: To study child-parent similarities and the heritability of corneal shape by applying a variance component model to videokeratographic data. METHODS: Sixteen astigmatic (keratometric cylinder >/= 1.0 D) and 18 nonastigmatic (keratometric cylinder < 1.0 D) children, 7-14 years of age (mean age, 9.5 years), were enrolled with their parents. Corneal curvature, corneal astigmatism (axis and magnitude), asphericity, corneal uniformity index, and Rabinowitz McDonnell inferior-superior dioptric asymmetry value (I-S value), as well as spherical and astigmatic topographic patterns, were determined by a corneal topographer. Child-parent comparisons were assessed through a 1-way analysis of variance and the chi test. For corneal curvature, corneal astigmatism, and asphericity, heritability was estimated by a variance component model after adjustments were made for age and sex. RESULTS: Both astigmatic and nonastigmatic children showed steeper keratometric values than their parents (P < 0.05). The axis values of corneal astigmatism showed no statistically significant difference (P = 0.684) between astigmatic offspring and their parents, whereas the magnitude values were significantly higher (P < 0.001) in astigmatic children. Altogether, 68% (95% confidence interval [CI], 66%-72%) of child-parent comparisons showed the same topographic pattern between parents and their offspring. Heritability values (48%; 95% CI, 36%-57%) were statistically significant for corneal curvature (P < 0.00001) and <30% for corneal astigmatism and asphericity. CONCLUSIONS: The application of a variance component model to videokeratographic child-parent comparisons suggests that the genetic contribution to corneal shape affects corneal curvature rather than corneal astigmatism.
2007
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/2445822
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