Electrospray mass spectrometry (ESI-MS) in the study of metal-ligand solution equilibria

In the 20 years, since the introduction of electrospray mass spectrometry (ESI-MS), the use of this technique in various fields of inorganic, organometallic, and analytical chemistry has been steadily increasing. In this study, the application of ESI-MS to the study of metal–ligand solution equilibria is reviewed (till 2004 included). In a first section, advantages and drawbacks of ESIMS in this type of application are described. Subsequently, a list of ca. 300 studies is reported, in which ESI-MS was used to give number and stoichiometry of the species at equilibrium, or also to estimate their stability constants. All studies are classified according to the metal ions under examination. Other related applications, such as host–guest interactions and metal ionprotein binding studies, are briefly reviewed as well.