Functionalization of tripodal scaffold molecules on solid support

A versatile synthetic approach is described for the functionalization of tripodal scaffold molecules on solid support. Intrinsic problems related to the attachment of tripodal scaffolds to a resin (for example mono- vs. polyadducts and intramolecular cyclizations) are studied and solutions are provided. The synthetic approach relies on the use of specific protecting groups in the critical steps of the synthesis. Importantly, however, protecting groups on the scaffold molecule are never used, which significantly facilitates scaffold variation, for instance in combinatorial studies. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).