Spontaneous resolution of idiopathic aldosteronism after long-term treatment with potassium canrenoate.

The results of the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study4 and the Randomized Aldactone Evaluation Study5 in fact show that aldosterone receptor blockers are effective in preventing cardiovascular complications, independent from the aldosterone value. Our data can strengthen this concept, showing that aldosterone receptor blockers also have a beneficial effect at the level of glomerulosa, restoring a normal reactivity to angiotensin II. In conclusion, our data are consistent either with an exhaustion of the biochemical picture of PA in patients treated for the long term with KC, with reversal of PA to essential hypertension, or with an age-related reduction of renin and aldosterone with restoration of normal reactivity of glomerulosa to aldosterone.