The difficult coupling of α-aminoisobutyric acid (Aib), during the synthesis of dipeptides (), was carried out using PyBOP/HOBt and HBTU/HOBt reagents by application of microwave energy in the presence of solvent. Room temperature, conventional heating (oil bath) and microwave irradiation of the reactions are compared. Synthesis by microwave irradiation gave the desired compounds in higher yields and in shorter reaction times than those obtained by conventional heating or at room temperature.
Microwave Enhaced Solution Coupling of the alpha-alpha-Dialkyl Amino Acid, Aib
DE FILIPPIS, VINCENZO;
2001
Abstract
The difficult coupling of α-aminoisobutyric acid (Aib), during the synthesis of dipeptides (), was carried out using PyBOP/HOBt and HBTU/HOBt reagents by application of microwave energy in the presence of solvent. Room temperature, conventional heating (oil bath) and microwave irradiation of the reactions are compared. Synthesis by microwave irradiation gave the desired compounds in higher yields and in shorter reaction times than those obtained by conventional heating or at room temperature.
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