A number of methyl furoquinolinones, methylpsoralen isosters, were synthesized. The synthesis was performed starting from the appropriate methyl quinolin-2-ones on which the methylfuran ring was condensed. The compounds showed high molar absorbitivity at long wavelength with an improvement of photobinding to the biological targets.
Methylfuroquinolinones: new furocoumarin isosters as potential photoreagents toward DNA.
GUIOTTO, ADRIANO;CHILIN, ADRIANA;PALUMBO, MANLIO
1989
Abstract
A number of methyl furoquinolinones, methylpsoralen isosters, were synthesized. The synthesis was performed starting from the appropriate methyl quinolin-2-ones on which the methylfuran ring was condensed. The compounds showed high molar absorbitivity at long wavelength with an improvement of photobinding to the biological targets.
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