Clinical, epidemiological and experimental data regarding the link between alcoohol abuse and cancer clearly demonstrates that ethanol plays an important role in carcinogenesis. This role is certainly more evident for organs exposed more directly and to higher ethanol concentrations, such as the upper alimentary tract. Ethanol may take part in carcinogenesis through several mechanisms: by its solvent effects, by inducing alimentary or immunological deficiencies, by acting as a vehicle for carcinogens, by facilitating their activation or by inhibiting DNA repair. The significance of these effects of ethanol in different tissues will be influenced by factors in vivo including the carcinogen detoxifying capacity of various tissues, the route of carcinogen exposure, and, in the alcohol-abuser in particular, the presence of ethanol in the circulation at the time of carcinogen exposure.

Alcohol metabolism in the upper digestive tract: its implications with respect to carcinogenesis.

FARINATI, FABIO;ZORDAN, MAURO AGOSTINO;BURRA, PATRIZIA;VENIER, PAOLA;NITTI, DONATO;LEVIS, ANGELO GINO;
1992

Abstract

Clinical, epidemiological and experimental data regarding the link between alcoohol abuse and cancer clearly demonstrates that ethanol plays an important role in carcinogenesis. This role is certainly more evident for organs exposed more directly and to higher ethanol concentrations, such as the upper alimentary tract. Ethanol may take part in carcinogenesis through several mechanisms: by its solvent effects, by inducing alimentary or immunological deficiencies, by acting as a vehicle for carcinogens, by facilitating their activation or by inhibiting DNA repair. The significance of these effects of ethanol in different tissues will be influenced by factors in vivo including the carcinogen detoxifying capacity of various tissues, the route of carcinogen exposure, and, in the alcohol-abuser in particular, the presence of ethanol in the circulation at the time of carcinogen exposure.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/2466105
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 2
  • ???jsp.display-item.citation.isi??? ND
social impact