We have shown how a dinuclear Zn2+ complex of a tailored 310- helical heptapeptide may act as a powerful catalyst for the hydrolytic cleavage of plasmid DNA. The precise distance between the two metal centers, as defined by the pitch of the helix, which matches that between two adjacent DNA phosphate groups, allows one to take advantage of the cooperation between the two Zn2+ ions in binding and performing the hydrolytic process.
Dinuclear Zn2+ complexes of synthetic heptapeptides as artificial nucleases
SISSI, CLAUDIA;ROSSI, PAOLA;FORMAGGIO, FERNANDO;PALUMBO, MANLIO;TONIOLO, CLAUDIO;SCRIMIN, PAOLO MARIA
2001
Abstract
We have shown how a dinuclear Zn2+ complex of a tailored 310- helical heptapeptide may act as a powerful catalyst for the hydrolytic cleavage of plasmid DNA. The precise distance between the two metal centers, as defined by the pitch of the helix, which matches that between two adjacent DNA phosphate groups, allows one to take advantage of the cooperation between the two Zn2+ ions in binding and performing the hydrolytic process.File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
