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EnglishThis review summarizes recent work on the regulation of the permeability transition pore, a cyclosporin A-sensitive mitochondrial channel that may play a role in intracellular calcium homeostasis and in a variety of forms of cell death. The basic bioenergetics aspects of pore modulation are discussed, with some emphasis on the links between oxidative stress and pore dysregulation as a potential cause of mitochondrial dysfunction that may be relevant to cell injury.
| Titolo: | The Mitochondrial Permeability Transition. |
| Autori: | |
| Data di pubblicazione: | 1998 |
| Rivista: | |
| Abstract: | This review summarizes recent work on the regulation of the permeability transition pore, a cyclosporin A-sensitive mitochondrial channel that may play a role in intracellular calcium homeostasis and in a variety of forms of cell death. The basic bioenergetics aspects of pore modulation are discussed, with some emphasis on the links between oxidative stress and pore dysregulation as a potential cause of mitochondrial dysfunction that may be relevant to cell injury. |
| Handle: | http://hdl.handle.net/11577/2467736 |
| Appare nelle tipologie: | 01.01 - Articolo in rivista |
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