Basement membranes (BMs) are extracellular laminar matrices produced by endothelial and epithelial cells. They are composed by three major intrinsic macromolecules: type IV collagen, laminin and heparan sulfate proteoglycan (HSP), and by two major extrinsic ones: fibronectin and type V collagen. The intrinsic components are assembled in a three-dimensional network (type IV collagen) to which cells stick (by laminin) and through which (HSP) they interact with the stromal compartment. The BM is a barrier to be crossed by any cell that leaves the stroma to enter into the circulation or vice versa. Metastatic tumor cells secrete a protease which specifically degrades the BM collagen and some evidence suggests that the same enzyme is used also by normal monocytes.

Macromolecular organization and functional architecture of basement membranes

GARBISA, SPIRIDIONE;NEGRO, ALESSANDRO
1984

Abstract

Basement membranes (BMs) are extracellular laminar matrices produced by endothelial and epithelial cells. They are composed by three major intrinsic macromolecules: type IV collagen, laminin and heparan sulfate proteoglycan (HSP), and by two major extrinsic ones: fibronectin and type V collagen. The intrinsic components are assembled in a three-dimensional network (type IV collagen) to which cells stick (by laminin) and through which (HSP) they interact with the stromal compartment. The BM is a barrier to be crossed by any cell that leaves the stroma to enter into the circulation or vice versa. Metastatic tumor cells secrete a protease which specifically degrades the BM collagen and some evidence suggests that the same enzyme is used also by normal monocytes.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/2470306
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