The influence of the vehicle on release and simulated absorption of methyl nicotinate (MN) was evaluated using in vitro systems in order to find a correlation with data previously obtained in vivo. Simulation of drug absorption was carried out using a porous polymer membrane soaked with lipophilic phases such as n-dodecanol and isopropyl myristate. Ointment composition influenced differently both release and absorption of MN independent of drug concentration. The degree of skin redness induced by MN was found to be significantly correlated to in vitro simulated drug absorption but not to in vitro drug release.

Kinetics of release and simulated absorpion of methyl nicotinate from different ointment formulations: in vitro-in vivo correlations

REALDON, NICOLA;RAGAZZI, EUGENIO;DAL ZOTTO, MARISA;RAGAZZI, ENRICO
1996

Abstract

The influence of the vehicle on release and simulated absorption of methyl nicotinate (MN) was evaluated using in vitro systems in order to find a correlation with data previously obtained in vivo. Simulation of drug absorption was carried out using a porous polymer membrane soaked with lipophilic phases such as n-dodecanol and isopropyl myristate. Ointment composition influenced differently both release and absorption of MN independent of drug concentration. The degree of skin redness induced by MN was found to be significantly correlated to in vitro simulated drug absorption but not to in vitro drug release.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/2470663
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