Four different approaches have been reviewed herein: i) nucleoside analogs as mock agents of the reverse transcriptase (hTERT) catalytic site; ii) miscellaneous molecules with unknown mechanism(s) of action; iii) inhibitors of upstream processes of regulation of the hTERT subunit; iiii) immunotherapy against immunogenic hTERT-derived peptides.
Alternative approaches to the discovery and development of telomerase-targeted anticancer drugs
RICHTER, SARA;PALUMBO, MANLIO
2003
Abstract
Four different approaches have been reviewed herein: i) nucleoside analogs as mock agents of the reverse transcriptase (hTERT) catalytic site; ii) miscellaneous molecules with unknown mechanism(s) of action; iii) inhibitors of upstream processes of regulation of the hTERT subunit; iiii) immunotherapy against immunogenic hTERT-derived peptides.
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