Strategy to enhance the osseo-inntegration process: synthetic peptides improving osteoblast adhesion on implant surface

In order to improve the integration process between surgically placed implants and biological tissues, next generation biomaterials have to be designed to enhance and support osteoblast adhesion. In fact, it has been demonstrated that the quality of the early cell/material interactions is highly responsible for the long-term functional response of implants. Polystyrene surfaces have been conditioned with different synthetic peptides and their ability in promoting osteoblast adhesion has been compared. The results obtained applying best performing peptides in osteoblast adhesion assays on acellular bone matrix are herewith discussed.