Ditazol (4,5-diphenyl-2 bis-hydroxyethylaminoxazol) was tested with regard to its effect in vivo and in vitro on platelet malonyladehyde (MDA) production which seems to be a good marker of prostaglandins metabolism. The drug is a powerful inhibitor of platelet MDA Production induced by thrombin in vitro and this action seems to be due to a "competitive" type effect. "In vivo" experiments showed a significant inhibitory effect on platelet MDA production 4--6 hours after administration of the drug, with return to basal levels within 24 hours.

In vitro and in vivo effects of ditazol on human platelets malonylaldehyde (MDA) production.

FABRIS, FABRIZIO;CASONATO, SANDRA;RANDI, MARIA LUIGIA;GIROLAMI, ANTONIO
1981

Abstract

Ditazol (4,5-diphenyl-2 bis-hydroxyethylaminoxazol) was tested with regard to its effect in vivo and in vitro on platelet malonyladehyde (MDA) production which seems to be a good marker of prostaglandins metabolism. The drug is a powerful inhibitor of platelet MDA Production induced by thrombin in vitro and this action seems to be due to a "competitive" type effect. "In vivo" experiments showed a significant inhibitory effect on platelet MDA production 4--6 hours after administration of the drug, with return to basal levels within 24 hours.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/2489952
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