Ditazol (4,5-diphenyl-2 bis-hydroxyethylaminoxazol) was tested with regard to its effect in vivo and in vitro on platelet malonyladehyde (MDA) production which seems to be a good marker of prostaglandins metabolism. The drug is a powerful inhibitor of platelet MDA Production induced by thrombin in vitro and this action seems to be due to a "competitive" type effect. "In vivo" experiments showed a significant inhibitory effect on platelet MDA production 4--6 hours after administration of the drug, with return to basal levels within 24 hours.
In vitro and in vivo effects of ditazol on human platelets malonylaldehyde (MDA) production.
FABRIS, FABRIZIO;CASONATO, SANDRA;RANDI, MARIA LUIGIA;GIROLAMI, ANTONIO
1981
Abstract
Ditazol (4,5-diphenyl-2 bis-hydroxyethylaminoxazol) was tested with regard to its effect in vivo and in vitro on platelet malonyladehyde (MDA) production which seems to be a good marker of prostaglandins metabolism. The drug is a powerful inhibitor of platelet MDA Production induced by thrombin in vitro and this action seems to be due to a "competitive" type effect. "In vivo" experiments showed a significant inhibitory effect on platelet MDA production 4--6 hours after administration of the drug, with return to basal levels within 24 hours.File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.