Phosphatidylserine (PS) vesicles incorporated into rat brain synaptosomes increased total Ca2+ uptake. Total Ca2+ uptake was resolved in three components: K+ depolarization-induced Ca2+ uptake, Na+/Ca2+ exchange, and passive Ca2+ entry, which were differently affected by PS depending on the amount of incorporated phospholipid. K+ depolarization-induced Ca2+ uptake was stimulated by 0.05-0.10 mumol PS/mg protein while 0.10-0.30 mumol PS/mg protein increased Na+/Ca2+ exchange activity and passive Ca2+ entry but not K+ depolarization-induced Ca2+ uptake. High amounts of incorporated PS also increased passive Rb+ uptake.

Phosphatidylserine vesicles increase Ca2+ uptake by rat brain synaptosomes.

DEBETTO, PATRIZIA;
1991

Abstract

Phosphatidylserine (PS) vesicles incorporated into rat brain synaptosomes increased total Ca2+ uptake. Total Ca2+ uptake was resolved in three components: K+ depolarization-induced Ca2+ uptake, Na+/Ca2+ exchange, and passive Ca2+ entry, which were differently affected by PS depending on the amount of incorporated phospholipid. K+ depolarization-induced Ca2+ uptake was stimulated by 0.05-0.10 mumol PS/mg protein while 0.10-0.30 mumol PS/mg protein increased Na+/Ca2+ exchange activity and passive Ca2+ entry but not K+ depolarization-induced Ca2+ uptake. High amounts of incorporated PS also increased passive Rb+ uptake.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/2495544
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