The conformational features of three tetrahydropyridinyl oxime cognition activators 1-(1-methyl-1,2,5,6-tetrahydro-3-pyridinyl)ethanone oxime.HCl (I), 1-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)ethanone oxime.HCl (II), and 1-(1,2,5,6-tetrahydro-3-pyridinyl)ethanone O-methyloxime HCl(III) were analyzed by X-ray diffraction and the quantum mechanical semiempirical PM3 methods. Results indicate that in the solid state the drugs exhibit "anti-syn" isomerism, with the substituent at the oxime oxygen atom anti oriented in respect to C = N. This arrangement also represents a low-energy situation in vacuo, as confirmed at the PM3 level, although another low-energy conformation ("clinal-anti") could be of significance in the conformational energetics of the drugs.
Titolo: | Conformation of three tetrahydropyridinyl oxime cognition activators |
Autori: | |
Data di pubblicazione: | 1991 |
Rivista: | |
Abstract: | The conformational features of three tetrahydropyridinyl oxime cognition activators 1-(1-methyl-1,2,5,6-tetrahydro-3-pyridinyl)ethanone oxime.HCl (I), 1-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)ethanone oxime.HCl (II), and 1-(1,2,5,6-tetrahydro-3-pyridinyl)ethanone O-methyloxime HCl(III) were analyzed by X-ray diffraction and the quantum mechanical semiempirical PM3 methods. Results indicate that in the solid state the drugs exhibit "anti-syn" isomerism, with the substituent at the oxime oxygen atom anti oriented in respect to C = N. This arrangement also represents a low-energy situation in vacuo, as confirmed at the PM3 level, although another low-energy conformation ("clinal-anti") could be of significance in the conformational energetics of the drugs. |
Handle: | http://hdl.handle.net/11577/2495718 |
Appare nelle tipologie: | 01.01 - Articolo in rivista |