Fast atom bombardment mass Spectrometry was employed in a study related to the hydrolytic degradation of alanine ethyl ester- and imidazole-substituted polyphosphazenes, to be used as matrices for drug release. Some intermediates were identified and their structural assignment was accomplished by means of mass-analysed ion kinetic energy data. All the detected species show the same phosphazene skeleton, consisting of a P4N3 chain, with an increasing number of alanine ethyl ester substituents, and no evidence was found for the presence of imidazole bound to the polymer backbone.
Fast atom bombardment in the structural identification of intermediates in the hydrolytic degradation of polyphosphazenes
CALICETI, PAOLO;
1992
Abstract
Fast atom bombardment mass Spectrometry was employed in a study related to the hydrolytic degradation of alanine ethyl ester- and imidazole-substituted polyphosphazenes, to be used as matrices for drug release. Some intermediates were identified and their structural assignment was accomplished by means of mass-analysed ion kinetic energy data. All the detected species show the same phosphazene skeleton, consisting of a P4N3 chain, with an increasing number of alanine ethyl ester substituents, and no evidence was found for the presence of imidazole bound to the polymer backbone.File in questo prodotto:
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