RE: “PARITY Doria-Rose e At aNl.D (1 T) HreEce RnItlSyK e xOaFm DinOedW pNar’iSty S aYsN aD riRskO fMacEto”r for Down’s syndrome and concluded that their data support an association between parity and Down’s syndrome at any age. However, as Chan (2) pointed out in the invited commentary that accompanied this Journal article, the Doria-Rose et al. paper suffers from some limitations, such as ascertainment of Down’s syndrome births and lack of data on prenatal diagnosis.Our data confirm a higher risk of a Down’s syndrome child limited to only those women with a parity of more than four. However, because this effect is evident for women only 35 years of age or older, its practical impact is null because these women are usually offered prenatal diagnosis in any case. However, understanding the mechanisms involved, if this association is true, is very intriguing and could stimulate scientific studies allowing better knowledge of the nondisjunction mechanisms.
Re: "parity and the risk of Down's syndrome".
CLEMENTI, MAURIZIO;
2004
Abstract
RE: “PARITY Doria-Rose e At aNl.D (1 T) HreEce RnItlSyK e xOaFm DinOedW pNar’iSty S aYsN aD riRskO fMacEto”r for Down’s syndrome and concluded that their data support an association between parity and Down’s syndrome at any age. However, as Chan (2) pointed out in the invited commentary that accompanied this Journal article, the Doria-Rose et al. paper suffers from some limitations, such as ascertainment of Down’s syndrome births and lack of data on prenatal diagnosis.Our data confirm a higher risk of a Down’s syndrome child limited to only those women with a parity of more than four. However, because this effect is evident for women only 35 years of age or older, its practical impact is null because these women are usually offered prenatal diagnosis in any case. However, understanding the mechanisms involved, if this association is true, is very intriguing and could stimulate scientific studies allowing better knowledge of the nondisjunction mechanisms.Pubblicazioni consigliate
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