Role of inositol 1,4,5-trisphosphate in excitation-contraction coupling in skeletal muscle.

Volpe, Pompeo; Di Virgilio, F; Pozzan, Tullio; Salviati, G.

The sarcoplasmic reticulum (SR) of skeletal muscle is an intracellular membranous network that controls the myoplasmic Ca2+ concentration and the contraction-relaxation cycle. Ca2+ release from the terminal cisternae (TC) region of the SR evokes contraction. How electrical depolarization of the transverse tubule is linked to Ca2+ release from the junctionally associated TC is still largely unknown. Independent evidence has been recently obtained indicating that either inositol trisphosphate (IP3) or (and) Ca2+ is (are) the chemical transmitter(s) of excitation-contraction coupling. Here we outline the experimental data in support of each transmitter and discuss possible interactive roles of Ca2+ and IP3.

Titolo:	Role of inositol 1,4,5-trisphosphate in excitation-contraction coupling in skeletal muscle.
Autori:	VOLPE, POMPEO Di Virgilio F POZZAN, TULLIO Salviati G. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1986
Rivista:	FEBS LETTERS
Abstract:	The sarcoplasmic reticulum (SR) of skeletal muscle is an intracellular membranous network that controls the myoplasmic Ca2+ concentration and the contraction-relaxation cycle. Ca2+ release from the terminal cisternae (TC) region of the SR evokes contraction. How electrical depolarization of the transverse tubule is linked to Ca2+ release from the junctionally associated TC is still largely unknown. Independent evidence has been recently obtained indicating that either inositol trisphosphate (IP3) or (and) Ca2+ is (are) the chemical transmitter(s) of excitation-contraction coupling. Here we outline the experimental data in support of each transmitter and discuss possible interactive roles of Ca2+ and IP3.
Handle:	http://hdl.handle.net/11577/2500370
Appare nelle tipologie:	01.01 - Articolo in rivista

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