Fenclor 64 (a PCB's commercial mixture) was administered twice i.p. to virgin and pregnant New Zealand rabbits at the dose of 100 mg/Kg to evaluate its inducing properties on the following hepatic microsomal MFO activities: p-nitro-anisole-O-demethylase, amino-pyrine-N-demethylase, acetanilide-hydroxylase and aryl-hydrocarbons-hydroxylase. The results indicate that Fenclor 64 evoked a "mixed type" induction in virgin as well as in pregnant rabbits since it increased liver weight, cytochrome P-450 levels, as well as p-nitro-anisole-O-demethylase and acetanilide-hydroxylase. Pregnancy by itself affects only amino-pyrine-N-demethylase levels.

Effect of PCB on some MFO enzyme activities in pregnant and virgin rabbits.

MONTESISSA, CLARA;
1987

Abstract

Fenclor 64 (a PCB's commercial mixture) was administered twice i.p. to virgin and pregnant New Zealand rabbits at the dose of 100 mg/Kg to evaluate its inducing properties on the following hepatic microsomal MFO activities: p-nitro-anisole-O-demethylase, amino-pyrine-N-demethylase, acetanilide-hydroxylase and aryl-hydrocarbons-hydroxylase. The results indicate that Fenclor 64 evoked a "mixed type" induction in virgin as well as in pregnant rabbits since it increased liver weight, cytochrome P-450 levels, as well as p-nitro-anisole-O-demethylase and acetanilide-hydroxylase. Pregnancy by itself affects only amino-pyrine-N-demethylase levels.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/2500791
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