Two C4-cycloadducts between 4′-methylangelicin and thymine were isolated from the photo-reaction (365 nm) between this furocoumarin and DNA. Their capacity to undergo photoreversion at 254 nm and their spectroscopic and NMR data allowed us to assign furan- and pyrone-side structures, respectively, to these photocompounds. The former adduct has a cis-syn configuration; the latter. which was also isolated from a photoreaction between the furocoumarin and thymine in water-methanol solution, was assigned a cis-anti structure.
3,4 AND 4',5'-PHOTOCYCLOADDUCTS BETWEEN 4'-METHYLANGELICIN AND THYMINE FROM DNA
CAFFIERI, SERGIO;MIOLO, GIORGIA;DALL'ACQUA, FRANCESCO
1988
Abstract
Two C4-cycloadducts between 4′-methylangelicin and thymine were isolated from the photo-reaction (365 nm) between this furocoumarin and DNA. Their capacity to undergo photoreversion at 254 nm and their spectroscopic and NMR data allowed us to assign furan- and pyrone-side structures, respectively, to these photocompounds. The former adduct has a cis-syn configuration; the latter. which was also isolated from a photoreaction between the furocoumarin and thymine in water-methanol solution, was assigned a cis-anti structure.
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