In cynomolgus monkeys, we compared two human-derived SIV(mac)251 whole virus vaccines, a long vs short immunization schedule, and two different challenge viruses. Both vaccines induced protection after challenge with human-derived SIV(mac)251/32H. There was no difference between the two schedules of immunization. Seven monkeys, five of which were protected following the first challenge, were reboosted and rechallenged with monkey-derived SIV(mac)251, but no protection was observed. The titers of anti-human cell or -SIV neutralizing antibodies were not related to protection.
Immunization of Macaca-fascicularis With Inactivated Siv Preparations - Challenge With Human-derived Or Monkey-derived Siv and the Effects of A Longer Immunization Schedule
AMADORI, ALBERTO;
1993
Abstract
In cynomolgus monkeys, we compared two human-derived SIV(mac)251 whole virus vaccines, a long vs short immunization schedule, and two different challenge viruses. Both vaccines induced protection after challenge with human-derived SIV(mac)251/32H. There was no difference between the two schedules of immunization. Seven monkeys, five of which were protected following the first challenge, were reboosted and rechallenged with monkey-derived SIV(mac)251, but no protection was observed. The titers of anti-human cell or -SIV neutralizing antibodies were not related to protection.
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