Perfused liver carnitine palmitoyl transferase (CPT) activity and ketone body output were determined in streptozotocin treated and untreated Sprague-Dawley and Zucker rats. Streptozotocin enhanced liver ketogenic capacity and CPT activity in both these strains. No difference was observed in CPT activity or in ketone body production between the fatty and lean Zucker strains. Glucagon, added directly to the perfusate, had no influence on ketone body output and only in the livers of obese Zucker rats increased CPT activity.
Perfused liver carnitine palmitoyl-transferase activity and ketogenesis in streptozotocin treated and genetic hyperinsulinemic rats. Effect of glucagon.
URSINI, FULVIO;Tessari P;
1979
Abstract
Perfused liver carnitine palmitoyl transferase (CPT) activity and ketone body output were determined in streptozotocin treated and untreated Sprague-Dawley and Zucker rats. Streptozotocin enhanced liver ketogenic capacity and CPT activity in both these strains. No difference was observed in CPT activity or in ketone body production between the fatty and lean Zucker strains. Glucagon, added directly to the perfusate, had no influence on ketone body output and only in the livers of obese Zucker rats increased CPT activity.
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