High plasma concentrations of triglycerides and low plasma concentrations of esterified cholesterol and lysolecithin, with an impaired rate of VLDL and LDL catabolism, have been reported in chronic uremic patients. An important contribution to these abnormalities might be an impaired activity of the (LCAT). Serum LCAT activity and cholesteryl ester clearance were determined in 11 patients with chronic renal failure and in 10 controls. LCAT activity was determined by using the serum of each patient both as a source of enzyme and as a substrate ('intrinsic' activity) and was compared with the activity determined on a standard substrate ('extrinsic' activity), so as to ascertain the presence of inhibitory factors in the patients' sera. Both activities have been found to be significantly (P < 0.01) lower in chronic uremic patients than in controls.
Lecithin-cholesterol acyltransferase (LCAT) activity in chronic uremia.
URSINI, FULVIO;
1978
Abstract
High plasma concentrations of triglycerides and low plasma concentrations of esterified cholesterol and lysolecithin, with an impaired rate of VLDL and LDL catabolism, have been reported in chronic uremic patients. An important contribution to these abnormalities might be an impaired activity of the (LCAT). Serum LCAT activity and cholesteryl ester clearance were determined in 11 patients with chronic renal failure and in 10 controls. LCAT activity was determined by using the serum of each patient both as a source of enzyme and as a substrate ('intrinsic' activity) and was compared with the activity determined on a standard substrate ('extrinsic' activity), so as to ascertain the presence of inhibitory factors in the patients' sera. Both activities have been found to be significantly (P < 0.01) lower in chronic uremic patients than in controls.
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