Mitochondrial glycerophosphate-acyltransferase activity (GPAT) was determined in the isolated and perfused liver of diet-induced hyperlipemic rats, and was found to be significantly increased compared to normal rats. A positive correlation existed between hepatic triglyceride output and GPAT. Perfusion of 10-5 M glucagon induced a significant reduction in GPAT levels. It is suggested that the lipid-lowering action of glucagon may be mediated also through an inhibition of GPAT activity. © 1981 Casa Editrice.
Glycerophosphate acetyltransferase activity in perfused liver of normal and hyperlipemic rats: glucagon effect.
TESSARI, PAOLO;AVOGARO, ANGELO;TIENGO, ANTONIO
1981
Abstract
Mitochondrial glycerophosphate-acyltransferase activity (GPAT) was determined in the isolated and perfused liver of diet-induced hyperlipemic rats, and was found to be significantly increased compared to normal rats. A positive correlation existed between hepatic triglyceride output and GPAT. Perfusion of 10-5 M glucagon induced a significant reduction in GPAT levels. It is suggested that the lipid-lowering action of glucagon may be mediated also through an inhibition of GPAT activity. © 1981 Casa Editrice.
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