The biocompatibility of semisynthetic polymers formed from hyaluronic acid esters has been studied using fibroblast cultures. The polymers, added to the culture medium, used either in powdered form or as thin membranes, behave as inert materials. The cells used in the experiments grow normally in the culture dishes. With regard to adhesiveness the cells were not able to spread on the biomembranes and tended to form isolated clusters of round cells. Human fibronectin, placental collagen (type I-IV) and fibrin could be stratified on biomembranes. When these molecules reacted with the biomaterial the film became suitable for fibroblasts spreading and growth.

In vitro studies on biocompatibility of hyaluronic acid esters

CORTIVO, ROBERTA;BRUN, PAOLA;ABATANGELO, GIOVANNI
1991

Abstract

The biocompatibility of semisynthetic polymers formed from hyaluronic acid esters has been studied using fibroblast cultures. The polymers, added to the culture medium, used either in powdered form or as thin membranes, behave as inert materials. The cells used in the experiments grow normally in the culture dishes. With regard to adhesiveness the cells were not able to spread on the biomembranes and tended to form isolated clusters of round cells. Human fibronectin, placental collagen (type I-IV) and fibrin could be stratified on biomembranes. When these molecules reacted with the biomaterial the film became suitable for fibroblasts spreading and growth.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/2503796
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 65
social impact