Lymphocytes from 6 normal subjects (3 male and 3 female) and from 3 patients with Fanconi's anemia (1 male and 2 female) were examined for the frequency of sister chromatid exchanges (S.C.E.) by the BrdU-acridine orange method. The mean frequency of S.C.E. was 4.58 ± 1.05 in normal subjects and 6.89 ± 3.14 for Fanconi's anemia patients, showing no significant increase. The results of this work and previous experience, reported in literature are discussed. In relation with increased tendency of Fanconi's anemia homozygotes and heterozygotes to development of malignancy, the sensitivity of S.C.E. in a chemical agents-cells system method is pointed out.
Sister chromatid Exchanges in three cases of Fanconi's anemia.
ANGLANI, FRANCA;
1979
Abstract
Lymphocytes from 6 normal subjects (3 male and 3 female) and from 3 patients with Fanconi's anemia (1 male and 2 female) were examined for the frequency of sister chromatid exchanges (S.C.E.) by the BrdU-acridine orange method. The mean frequency of S.C.E. was 4.58 ± 1.05 in normal subjects and 6.89 ± 3.14 for Fanconi's anemia patients, showing no significant increase. The results of this work and previous experience, reported in literature are discussed. In relation with increased tendency of Fanconi's anemia homozygotes and heterozygotes to development of malignancy, the sensitivity of S.C.E. in a chemical agents-cells system method is pointed out.
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