Pyrolysis-GC/MS has been employed to characterize the products arising from the interaction between glucose and albumin. The pyrolysis products of genuine bovine serum albumin and glycated bovine serum albumin have been compared, after an extensive study devoted to the optimization of the pyrolysis conditions. Clear differences between the pyrograms of glycated and non-glycated samples have been found, confirming the validity of such an analytical approach. The structures of some components, characteristic of glycation, have been tentatively assigned on the basis of a mass spectra library search.
Pyrolysis-gas Chromatography Mass-spectrometry In the Characterization of Glycated Albumin
LAPOLLA, ANNUNZIATA;FAVRETTO, DONATA;
1992
Abstract
Pyrolysis-GC/MS has been employed to characterize the products arising from the interaction between glucose and albumin. The pyrolysis products of genuine bovine serum albumin and glycated bovine serum albumin have been compared, after an extensive study devoted to the optimization of the pyrolysis conditions. Clear differences between the pyrograms of glycated and non-glycated samples have been found, confirming the validity of such an analytical approach. The structures of some components, characteristic of glycation, have been tentatively assigned on the basis of a mass spectra library search.
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