In 10 patients with CLL and in 8 controls T lymphocytes were separated out by the rosetting method. The in vitro reactivity of these cells and of unseparated lymphocytes was studied in cultures without stimulants. A net increase of spontaneous lymphocyte transformation was found in the populations enriched with T cells in patients with CLL with respect to analogous populations in the controls. This increase is interpreted as a cell-mediated immunologic reaction and due to T-cell sensitization towards the neoplastic B cells.
Spontaneous lymphocyte transformation in chronic lymphocytic leukaemia.
SEMENZATO, GIANPIETRO CARLO;AMADORI, GIUSEPPE;GASPAROTTO, GIUSEPPE
1977
Abstract
In 10 patients with CLL and in 8 controls T lymphocytes were separated out by the rosetting method. The in vitro reactivity of these cells and of unseparated lymphocytes was studied in cultures without stimulants. A net increase of spontaneous lymphocyte transformation was found in the populations enriched with T cells in patients with CLL with respect to analogous populations in the controls. This increase is interpreted as a cell-mediated immunologic reaction and due to T-cell sensitization towards the neoplastic B cells.
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