The metabolic fate of [U-14C]glutamate administered intravenously to rats in aqueous solutions or entrapped in vescicles of phospholipids extracted from rat brain has been studied. When [U-14C]glutamate was administered entrapped in liposomes, higher serum radioactivity levels and higher radioactivity uptake by liver and brain were observed. Rats treated with [U-14C]glutamate entrapped in liposomes exhibited an increased glutamate oxidation shown by increased expired [14C]CO2 and a modified elimination of the radioactivity in urine. © 1976.
Uptake and metabolic rate of liposome-entrapped (U-14C)glutamate in rats.
BRANCA, DONATA;SCUTARI, GUIDO;SILIPRANDI, NORIS
1976
Abstract
The metabolic fate of [U-14C]glutamate administered intravenously to rats in aqueous solutions or entrapped in vescicles of phospholipids extracted from rat brain has been studied. When [U-14C]glutamate was administered entrapped in liposomes, higher serum radioactivity levels and higher radioactivity uptake by liver and brain were observed. Rats treated with [U-14C]glutamate entrapped in liposomes exhibited an increased glutamate oxidation shown by increased expired [14C]CO2 and a modified elimination of the radioactivity in urine. © 1976.
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