Wistar albino rats were intravenously injected with 1 mi of an oxyphoretic emulsion of perfluorobutylfurane and killed 3, 7 or 30 days later. Mitochondria isolated from the liver and kidneys of treated rats showed a small decrease in the transmembrane electrical potential and a substantial depression of the rates of both ATP synthesis and ADP-stimulated respiration. These alterations in mitochondrial oxidative phosphorylation appear to be induced by perfluorocarbon and/or tensioactive molecules interacting with hydrophobic cell structures.
Alteration of mitochondrial bioenergetics due to intravenous injection of a perfluorocarbon emulsion.
BRANCA, DONATA;CHIARELLI, SILVIA;VINCENTI, EZIO;TORTORELLA, CINZIA;SCUTARI, GUIDO
1994
Abstract
Wistar albino rats were intravenously injected with 1 mi of an oxyphoretic emulsion of perfluorobutylfurane and killed 3, 7 or 30 days later. Mitochondria isolated from the liver and kidneys of treated rats showed a small decrease in the transmembrane electrical potential and a substantial depression of the rates of both ATP synthesis and ADP-stimulated respiration. These alterations in mitochondrial oxidative phosphorylation appear to be induced by perfluorocarbon and/or tensioactive molecules interacting with hydrophobic cell structures.
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