NanoChlor, a nanoparticle-based fluorescent probe for chloride that is both ratiometric and capable of spontaneously penetrating neuronal cells at submillimolar concentrations, was designed and studied. NanoChlor is built on silica nanoparticles grafted with 6-methoxyquinolinium as the chloride-sensitive component and fluorescein as the reference dye. A Stern–Volmer constant of 50 M–1 was measured in Ringer’s buffer at pH 7.2, and the response to chemically induced chloride currents was recorded in real time in hippocampal cells.

A Cell-Penetrating Ratiometric Nanoprobe for Intracellular Chloride

BAU, LUCA;SELVESTREL, FRANCESCO;ARDUINI, MARIA;ZAMPARO, ILARIA;LODOVICHI, CLAUDIA;MANCIN, FABRIZIO
2012

Abstract

NanoChlor, a nanoparticle-based fluorescent probe for chloride that is both ratiometric and capable of spontaneously penetrating neuronal cells at submillimolar concentrations, was designed and studied. NanoChlor is built on silica nanoparticles grafted with 6-methoxyquinolinium as the chloride-sensitive component and fluorescein as the reference dye. A Stern–Volmer constant of 50 M–1 was measured in Ringer’s buffer at pH 7.2, and the response to chemically induced chloride currents was recorded in real time in hippocampal cells.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/2510555
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