The compounds tested were 4,7 dimethoxy, 4 hydroxy 7 methoxy and 4,7 dihydroxyindoles and indole 4,7 quinones. Only the dihydroxy compounds were active against certain bacterial strains. To test whether the action mechanism was analogous to that of mitomycin, experiments were carried out to study the formation of complexes with DNA. Only the substances with antimicrobial activity formed complexes, and it is therefore suggested that the action mechanism involves interference with cellular DNA.
Antimicrobial properties of some 3-acyl-4,7-disubstituted indoles.
DALL'ACQUA, FRANCESCO;VEDALDI, DANIELA ESTER
1975
Abstract
The compounds tested were 4,7 dimethoxy, 4 hydroxy 7 methoxy and 4,7 dihydroxyindoles and indole 4,7 quinones. Only the dihydroxy compounds were active against certain bacterial strains. To test whether the action mechanism was analogous to that of mitomycin, experiments were carried out to study the formation of complexes with DNA. Only the substances with antimicrobial activity formed complexes, and it is therefore suggested that the action mechanism involves interference with cellular DNA.
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