The action of hexavalent chromium (potassium chromate) and trivalent chromium (chromium chloride) on the mitotic cycle and the induction of chromosome aberrations and of sister chromatid exchanges have been analyzed in human and Chinese hamster cell lines in vitro. Eoth Cr6+ and Cr3+ are able to induce mitotic alterations but rather specific mechanisms of actions, leading to blockages in different mitotic phases, characterize each of the two compounds. Chromosome aberrations are almost doubled after treatment with 0.15 μg/ml of Cr6+ and 50 μg/ml of Cr3+, chromatid gaps, breaks and interchanges being the most frequent aberrations induced. On the other hand the frequency of sister chromatid exchanges is significantly increased after exposure to Cr6+, but not to Cr3+. © 1979 Taylor and Francis Group, LLC.
Mitotic alterations, chromosome aberrations and sister chromatid exchanges induced by hexavalent and trivalent chromium on mammalian cells in vitro.
MAJONE, FRANCA;
1979
Abstract
The action of hexavalent chromium (potassium chromate) and trivalent chromium (chromium chloride) on the mitotic cycle and the induction of chromosome aberrations and of sister chromatid exchanges have been analyzed in human and Chinese hamster cell lines in vitro. Eoth Cr6+ and Cr3+ are able to induce mitotic alterations but rather specific mechanisms of actions, leading to blockages in different mitotic phases, characterize each of the two compounds. Chromosome aberrations are almost doubled after treatment with 0.15 μg/ml of Cr6+ and 50 μg/ml of Cr3+, chromatid gaps, breaks and interchanges being the most frequent aberrations induced. On the other hand the frequency of sister chromatid exchanges is significantly increased after exposure to Cr6+, but not to Cr3+. © 1979 Taylor and Francis Group, LLC.
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