Among variuos furocoumarins studied , RBC hemolysis was significantly induced only by Psoralen and 3-CPS, although at higher concentrations than those used for photochemotherapeutic experiments. By pre-irradiating the compounds in methanol, and adding the solution to the RBC, damage on the cell membrane (hemolysis) was observed in various compounds, thus indicating a role of photoproducts in this toxic process.
DARK AND PHOTOHEMOLYSIS OF ERYTHROCYTES BY FUROCOUMARINS
VEDALDI, DANIELA ESTER;CAFFIERI, SERGIO;MIOLO, GIORGIA;DALL'ACQUA, FRANCESCO;
1988
Abstract
Among variuos furocoumarins studied , RBC hemolysis was significantly induced only by Psoralen and 3-CPS, although at higher concentrations than those used for photochemotherapeutic experiments. By pre-irradiating the compounds in methanol, and adding the solution to the RBC, damage on the cell membrane (hemolysis) was observed in various compounds, thus indicating a role of photoproducts in this toxic process.File in questo prodotto:
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